Immunology

Chrug-Strauss syndrome: symptoms and signs Hi Yield [ID 3054]
PAVE:
P-ANCA
Asthma
Vasculitis
Eosinophilia
Knowledge Level 3, System: Cardiovascular
Marcus Fidel UNM School of Medicine
Graves disease: etiology [ID 2319]
In Graves disease, the thyroid-stimulating immunoglobulins are of the IgG class.
Knowledge Level 5, System: Endocrine
Anonymous Contributor
Lupus signs and symptoms Hi Yield [ID 321]
SOAP BRAIN:
Serositis [pleuritis, pericarditis]
Oral ulcers
Arthritis
Photosensitivity
Blood [all are low - anemia, leukopenia, thrombocytopenia]
Renal [protein]
ANA
Immunologic [DS DNA, etc.]
Neurologic [psych, seizures]
Knowledge Level 4, System: Integumental
Ken Evans Saskatchewan Health, Acute and Emergency Services
Acute inflammation features [ID 249]
SLIPR:
Swelling
Loss of function
Increased heat
Pain
Redness
 "What a cute pair of slippers" can be used to tie acute inflammation to SLIPR.
Knowledge Level 1, System: Lymphoid
Robert O'Connor University College Dublin
Celiac sprue features Hi Yield [ID 811]
CELIAC:
Cell-mediated autoimmune disease
European descent
Lymphocytes in Lamina propria/ Lymphoma risk
Intolerance of gluten (wheat)
Atrophy of villi in small intestine/ Abnormal D-xylose test
Childhood presentation
 Atrophied villi cause less absorption, so diarrhea, weight loss, less energy.
Knowledge Level 3, System: Lymphoid
Robert O'Connor University College Dublin
Complement cascade initiating items: alternative vs. classic Hi Yield [ID 783]
Classic: Combined Complexes.
Alternative: Activators Alone, or IgA.
 Complexes are made of Ab and Ag combined together.
 Examples of activators: endotoxin, microbial surface.
Knowledge Level 2, System: Lymphoid
Robert O'Connor University College Dublin
Complement: function of C3a versus C3b Hi Yield [ID 485]
C3a: Activates Acute [inflammation].
C3b: Bonds Bacteria [to macrophages--easier digestion].
 If wish to know more than just C3:
C3a, C4a, C5a activate acute.
C3b, C4b bind bacteria.
Knowledge Level 2, System: Lymphoid
Robert O'Connor and Marcus Fidel University College Dublin and UNM
Dendritic cell: function [ID 2590]
DENDRITIC CELL:
Disguised in host tissue (but still have same function!)
ECF ingestion
Nothing left to chance (ensures an immune response)
Derived from bone marrow
Regulates the immune response
Induces an immune response (makes it unique among antigen presenting cells)
Transfers information from the ECF into the cell
Immune tolerance (increases it)
Co-ordinates the adaptive and innate immune systems
Captures and processes antigen
Expresses lymphocyte costimulatory molecules
Llong processes extend from cell (stellate shaped)
Lives in lymphoid tissue
Secretes cytokine to initiate immune response
Knowledge Level 3, System: Lymphoid
Dave Colbert Faculty of Medicine, University of Western Australia
DiGeorge Syndrome: features Hi Yield [ID 2773]
The disease of T's:
Third and 4th pharyngeal pouch absent.
Twenty-Two chromosome
T-cells absent
Tetany: hypocalcemia
Knowledge Level 2, System: Lymphoid
Anonymous Contributor
Goodpasture's Syndrome components Hi Yield [ID 467]
GoodPasture is Glomerulonephritis and Pnuemonitits.
 From autoantibodies attacking Glomerular and Pulmonary basement membranes.
Knowledge Level 3, System: Lymphoid
Robert O'Connor University College Dublin
Histamine: features [ID 1453]
HISTAMINE:
HCL production
Inflammation
Strong vasodilator
Therapeutic vaue none
Allergy
Mast cells
Neurotransmitter/ Narrow airways
IgE
Knowledge Level 4, System: Lymphoid
Dr. Atif Farooq Rawalpindi Medical College, Pakistan, Gujranwala
HLA-B27 associated diseases [ID 1338]
PAIR:
Psoriasis
Ankylosing spondylitis
Inflammatory bowel disease
Reiter's syndrome
Knowledge Level 6, System: Lymphoid
Atif Farooq Khawaja Rawalpindi Medical College, Horizon Medical Institute, Pakistan
HLA-DR genetic predisposition immune disease examples [ID 629]
HLA-DR:
Hashimoto's disease
Leukemia/ Lupus
Autoimmune adrenalitis/ Anemia (pernicious)
Diabetes insipidous
Rheumatoid arthritis
Knowledge Level 8, System: Lymphoid
Robert O'Connor and Dr. Chetan Wiskar
Hypersensitivity reactions: Gell and Goombs nomenclature Hi Yield [ID 104]
ACID
 From I to IV:
Anaphylactic type: type I
Cytotoxic type: type II
Immune complex disease: type III
Delayed hypersensitivity (cell mediated): type IV
Knowledge Level 1, System: Lymphoid
Anonymous Contributor
Hypersensitivity: type IV example [ID 838]
Poison IVy causes type IV hypersensitivity.
Knowledge Level 4, System: Lymphoid
Anonymous Contributor
Immunoglobulin (Ig) types: the important ones worth remembering, in order of appearance Hi Yield [ID 106]
MAGDElaine (a girl's name):
IgM
IgA
IgG
IgD
IgE
 Magdelaine tells you the order they usually appear: M first, then A or G.
 Alternatively: IgM is IMmediate.
Knowledge Level 1, System: Lymphoid
Magdelaine Deeby and Anonymous Contributor University College Dublin and University of Aberdeen
Immunoglobulins, and order B cells present them Hi Yield [ID 2131]
MADGE (character from the old dishwashing liquid commercial):
IgM
IgA
IgD
IgG
IgE
 Order of presentation by B cells (which is made first, IgD or IgM?) B cells present IgM primarily, and then IgD.
Just remember why all of us are going through this pain...to become M.D's. For a B cell to be competent, it must get its MD.
 Finally, by the same rule, B cells must first release M then G immunoglobulin on primary exposure.
Knowledge Level 1, System: Lymphoid
Tevis Anthony Verrett Creighton University School of Medicine
Immunoglobulins: which crosses the placenta [ID 870]
IgG crosses the placenta during Gestation.
Knowledge Level 2, System: Lymphoid
Anonymous Contributor
Interferon gamma: action on macrophages Hi Yield [ID 877]
"Th1nk BIG Mac Attack":
Th1 and NK cells Build Interferon Gamma.
Causes Macrophages to have an augmented Attack [by better lysosome function and increasing reactive oxygen metabolites, nitric oxide and
defensins].
Knowledge Level 4, System: Lymphoid
Lior Greenberg Technion Faculty of Medicine, Haifa, Israel
MHC I vs. II: T cell interaction Hi Yield [ID 105]
The "=8" equation:
2x4=8, and 1x8=8.
MHC II goes with CD4.
MHC I goes with CD8.
Knowledge Level 1, System: Lymphoid
Anonymous Contributor
MHC I vs. MHC II properties Hi Yield [ID 625]
"Immunity helps to exterminate fun for bacteria"
 See attached chart.
Knowledge Level 3, System: Lymphoid
Robert O'Connor University College Dublin
MHC: loci creating class I vs. II [ID 2089]
Class 1 has 1 letter:
HLA I is HLA-A, HLA-B, HLA-C.
Class 2 has 2 letters:
HLA II is HLA-DP, HLA-DQ, HLA-DR.
Knowledge Level 6, System: Lymphoid
Anonymous Contributor
Passive vs. active immunity [ID 961]
"Pay for Passive, Active Ages":
Passive:Pay for a shot of antibodies for fast results following exposure to Rabies, etc.
Active: Slow onset ("aging") and memory.
Knowledge Level 1, System: Lymphoid
Lior Greenberg Technion Faculty of Medicine, Haifa, Israel
Sjogren syndrome: morphology Hi Yield [ID 796]
"Jog through the MAPLES":
 Sjogren is:
Mouth dry
Arthritis
Parotid enlarged
Lymphoma
Eyes dry
Sicca (primary) or Secondary
 See diagram.
Knowledge Level 2, System: Lymphoid
Robert O'Connor University College Dublin
T and B cells: types Hi Yield [ID 1982]
When bacteria enter body, T-cell says to B: "Help Me Catch Some!" B-cell replies: "My Pleasure!":
 T-cell types:
Helper
Memory
Cytotoxic
Suppressor
 B-cell types:
Memory cell
Plasma cell
Knowledge Level 1, System: Lymphoid
Dr. Harsh Sharma BJMC, Pune, India